منابع مشابه
Cell Transformation by RNA Viruses: An Overview
Studies of oncogenic viruses have made seminal contributions to the molecular biology of cancer. Key discoveries include the identification of viral oncogenes and cellular proto-oncogenes, elucidation of signal transduction pathways, and identification of tumor suppressor genes. The origins of cancer virology began almost exactly one hundred years ago with the discovery of avian sarcoma and acu...
متن کاملReversal of malignant transformation by tumor DNA.
Walker-256 carcinosarcoma cells grown in tissue culture medium containing inhibitory DNA prepared from the tumor are shown to have an unaltered growth in vitro, but a diminished capacity to produce malignant tumors on injection into the rat. Coincident with this change in virulence is the induction of tRNA methylase inhibitors in these malignant cells. Within days after the DNA is removed from ...
متن کاملMalignant transformation of osteoblastoma.
A recurrent spinal tumor confidently diagnosed as osteoblastoma eventually terminated as a sclerosing osteoblastic which metastasised nine years after the onset of symptoms.
متن کاملConcepts in malignant transformation.
The precise biochemical nature of malignant transformation remains elusive. This article reviews some of the current theories of oncogenesis and aims to synthesize these concepts into a possible schema for the origins of malignant transformation, using a cell-programmed origin for neoplastic progression. It is proposed that cell transformation in malignancy is initiated by injury but finds ulti...
متن کاملIn Vitro Transformation by the Adenovirus-sv40 Hybrid Viruses
Primary weanling hamster kidney cultures were transformed with the adeno 2-SV40, adeno 3-SV40, and adeno 12-SV40 hybrid viruses and with adenovirus type 12. The transformed cell lines which were established were characterized with respect to morphology, virus and antigen content, and chromosome aberrations. The adeno 2 and adeno 3-SV40 hybrid transformed cells had the morphology and T antigen c...
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ژورنال
عنوان ژورنال: Journal of Medical Genetics
سال: 1967
ISSN: 1468-6244
DOI: 10.1136/jmg.4.2.143